Interleukin-4 (IL-4) is a multifunctional cytokine that plays an important role in immune and
inflammatory responses. Expression of the IL-4 gene is tightly controlled at the level of gene …

Abstract Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the
differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is …

BACKGROUND: The transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of
several T-cell cytokine genes, but the expression and contribution of this factor to cytokine …

Ubiquitously expressed transcription factor Yin Yang 1 (YY1) has long been believed to play
some role in immunoglobulin gene regulation, because it associates with multiple Ig …

Abstract Yin Yang 1 (YY1) is a zinc finger protein that functions as a transcriptional activator
or repressor and participates in multiple biological processes, including development and …

Our group has previously reported that the nuclear factor Yin-Yang 1 (YY1), a ubiquitous
DNA-binding protein, is able to interact with a silencer element (BE) in the gamma interferon …

Overexpression of the ERBB2 oncogene is observed in about 30% of breast cancers and is
generally correlated with a poor prognosis. Previous results from our and other laboratories …

The Th2 locus control region (LCR) has been shown to be important in efficient and
coordinated cytokine gene regulation during Th2 cell differentiation. However, the molecular …

The genetic defects underlying the pathogenesis of acute myeloid leukemia (AML) are still
largely unknown. Retroviral insertion mutagenesis in mice has become a powerful tool to …

It has been well-documented that transcription factors play pivotal roles in cell growth
control, development and differentiation. Defects in these proteins have been correlated with …