Disturbed glucose brain metabolism after brain trauma is reflected by changes in
extracellular glucose levels. The authors hypothesized that posttraumatic reductions in …

Objective: To study cerebral glucose and lactate metabolism in head-injured patients using
microdialysis. Design: Prospective, nonrandomized, clinical study. Setting: Neurosurgical …

Objectives: To analyze the effect of tight glycemic control with the use of intensive insulin
therapy on cerebral glucose metabolism in patients with severe brain injury. Design …

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of
injured brains. To that end, we utilized dual isotope tracer [6, 6-2H2] glucose, that is, D2 …

Utilizing [18F] fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the
correlation between CMRglc and the level of consciousness within the first month following …

Objective: To determine the effects of tight glycemic control on brain metabolism after
traumatic brain injury using brain positron emission tomography and microdialysis. Design …

✓ Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a
pathophysiological response to injury-induced ionic and neurochemical cascades. This …

The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into
the brain and its subsequent metabolism. We review the methods used to study cerebral …

Ischemic brain injury is the third-leading cause of death among Americans and the leading
cause of serious disability. Based on studies of animal models, a substantial amount of …

Background Microdialysis continuously monitors the chemistry of a small focal volume of the
cerebral extracellular space. Positron emission tomography (PET) establishes metabolism of …