The authors hypothesized that early relapse (eg, within 2–3 weeks or 1 month after
antidepressant discontinuation) in placebo recipients might represent antidepressant …

Background: Discontinuing antidepressants after recovering from a depressive episode is
associated with a risk for two events: discontinuation symptoms and relapse. Little is known …

Background Antidepressant discontinuation symptoms are becoming an increasingly
important part of clinical practice, but the incidence of antidepressant discontinuation …

Background Several national guidelines include recommendations for a minimum duration
of antidepressant treatment, but these vary from 4–9 months after remission. We aimed to …

Patients who stop their antidepressants are at risk for the antidepressant discontinuation
syndrome, especially if they abruptly stop the drug, taper it too quickly, or switch to a new …

Depressive disorders require long-term treatment with antidepressants, psychotherapy, or
both. The goal of antidepressant therapy is complete remission of symptoms and return to …

To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary
for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life …

The optimal duration of antidepressant treatment for patients with major depressive disorder
to reduce the risk of relapse after discontinuation remains uncertain. Medline, Cochrane …

Twenty eight patients treated with selective serotonin reuptake inhibitors/venlafaxine were
randomized to a three-day (short) or 14-day (longer) anti—depressant taper and openly …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …