The role of interleukin-1 in general pathology

N Kaneko, M Kurata, T Yamamoto, S Morikawa… - Inflammation and …, 2019 - Springer
Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities

P Galozzi, S Bindoli, A Doria, P Sfriso - Autoimmunity reviews, 2021 - Elsevier
The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Interleukin-1 function and role in rheumatic disease

G Schett, JM Dayer, B Manger - Nature Reviews Rheumatology, 2016 - nature.com
Abstract Interleukin (IL)-1, first described∼ 35 years ago as a secreted product of monocytes
and neutrophils, refers to IL-1α and IL-1β, two key cytokines in the activation of innate …

Interleukin 1α and the inflammatory process

NC Di Paolo, DM Shayakhmetov - Nature immunology, 2016 - nature.com
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection
and ultimately involves the recruitment and retention of cells of hematopoietic origin, which …

[HTML][HTML] Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases

G Cavalli, S Colafrancesco, G Emmi, M Imazio… - Autoimmunity …, 2021 - Elsevier
Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

Alternative pathways of IL-1 activation, and its role in health and disease

K Pyrillou, LC Burzynski, MCH Clarke - Frontiers in immunology, 2020 - frontiersin.org
Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …

The role of the interleukin‐1 family in trained immunity

SJ Moorlag, RJ Röring, LAB Joosten… - Immunological …, 2018 - Wiley Online Library
Immunological memory was long considered a trait exclusive to cells of the adaptive
immune system. However, recent studies have shown that after activation of the innate …

[HTML][HTML] Interleukin-6 signalling in health and disease

S Rose-John - F1000Research, 2020 - ncbi.nlm.nih.gov
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can
be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 …

[HTML][HTML] The interleukin-1 family: back to the future

C Garlanda, CA Dinarello, A Mantovani - Immunity, 2013 - cell.com
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Interleukin-1 and related cytokines in the regulation of inflammation and immunity

A Mantovani, CA Dinarello, M Molgora, C Garlanda - Immunity, 2019 - cell.com
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …