Does therapeutic drug monitoring (TDM) of trough concentrations suffice for optimizing preemptive therapy with ganciclovir of cytomegalovirus infections in non‐renal …

M Gatti, M Rinaldi, L Potena… - Transplant Infectious …, 2023 - Wiley Online Library
Objectives The aim of this study is to explore the relationship between ganciclovir exposure
and clinical efficacy and/or safety in non‐renal solid organ transplant (SOT) recipients …

[HTML][HTML] Therapeutic drug monitoring of ganciclovir in cytomegalovirus-infected patients with solid organ transplants and its correlation to efficacy and toxicity

LC Van der Wekken-Pas, J Totté, FV Lunel… - Therapeutic drug …, 2023 - journals.lww.com
Background: Cytomegalovirus causes morbidity and mortality, especially in
immunocompromised patients, and is treated with (val) ganciclovir. Therapeutic drug …

[HTML][HTML] Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R-transplant recipients

N Perrottet, O Manuel, F Lamoth, JP Venetz… - BMC infectious …, 2010 - Springer
Background Valganciclovir, the oral prodrug of ganciclovir, has been demonstrated
equivalent to iv ganciclovir for CMV disease treatment in solid organ transplant recipients …

Optimization of Ganciclovir use in allogeneic hematopoietic cell transplant recipients–the role of therapeutic drug monitoring

SA Ho, M Slavin, JA Roberts, M Yong - Expert Review of Anti …, 2021 - Taylor & Francis
Introduction: Cytomegalovirus (CMV) is an opportunistic infectious complication that can
occur after allogeneic hematopoietic cell transplantation (HCT). The mainstay of treatment …

Clinical pharmacokinetic monitoring and resistance testing for the optimisation of antiviral therapy targeting human cytomegalovirus

D Wong - 2022 - unsworks.unsw.edu.au
Cytomegalovirus (CMV) breakthrough despite therapy with ganciclovir remains a problem,
particularly for solid organ transplant (SOT) patients. This could be owing to inadequate …

Impact of initial cytomegalovirus viral load on efficacy of preemptive therapy with ganciclovir in allogeneic stem cell transplant recipients

J Torre-Cisneros, JJ Caston-Osorio… - Enfermedades …, 2009 - europepmc.org
Objective To study the impact of initial cytomegalovirus (CMV) viral load on virological
response to ganciclovir preemptive therapy in allogeneic stem cell transplant (SCT) …

DOSING OF INTRAVENOUS GANCICLOVIR FOR THE PROPHYLAXIS AND TREATMENT OF CYTOMEGALOVIRUS INFECTION IN SOLID ORGAN TRANSPLANT …

JA Fishman, MT Doran, SA Volpicelli, AB Cosimi… - …, 2000 - journals.lww.com
Background. The optimal regimen for the prevention and treatment of cytomegalovirus
(CMV) disease in solid organ transplant recipients remains to be defined, particularly for …

Ganciclovir in solid organ transplant recipients: is there a role for clinical pharmacokinetic monitoring?

JC Scott, N Partovi, MHH Ensom - Therapeutic drug monitoring, 2004 - journals.lww.com
The authors use a previously published decision-making algorithm to address the role of
clinical pharmacokinetic monitoring of ganciclovir, the drug of choice for prophylaxis and …

Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with …

A Caldés, H Colom, Y Armendariz… - Antimicrobial agents …, 2009 - Am Soc Microbiol
ABSTRACT A population pharmacokinetics analysis was performed after intravenous
ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus …

Monitoring of Trough Plasma Ganciclovir Levels and Peripheral Blood Cytomegalovirus (CMV)-Specific CD8+ T Cells To Predict CMV DNAemia Clearance in …

E Giménez, C Solano, JR Azanza, P Amat… - Antimicrobial Agents …, 2014 - Am Soc Microbiol
It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting
cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell …