In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of
inflammation. In human arthritis the majority of IL-17–secreting cells within the joint express …

Inflammatory T cells are thought to be central to the pathology of autoimmune arthritis. Th17
cells, CD4 T cells that secrete the pro-inflammatory cytokine IL-17 play a critical role in …

Objective To delineate the role of Th17 cells in the pathogenesis of autoimmune arthritides.
Methods Th17 cells were analyzed in well‐defined homogeneous cohorts of patients with …

CD4+ T cells differentiate into distinct subsets with unique functions and patterns of cytokine
secretion, such as the subsets termed Th1 and Th2. 1 Th1 cells produce interferon (IFN)-g …

Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental
arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis …

Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases,
including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells …

While T cells have been implicated in the pathogenesis of inflammatory arthritis for more
than three decades, the focus on the T helper type 17 (Th17) subset of CD4 T cells and their …

Aberrant helper T cell activation has been implicated in the pathogenesis of an array of
autoimmune diseases. In this review, we summarize evidence that suggests the involvement …

Objectives T helper 17 (Th17) cells from patients with early rheumatoid arthritis (RA) induce
a proinflammatory feedback loop upon RA synovial fibroblast (RASF) interaction, including …

Abstract Introduction Interleukin (IL)-17 is a proinflammatory cytokine that is produced
largely by a unique CD4+ T-helper (Th) subset called Th17 cells. The development of Th17 …