Cognitive decline in Parkinson's disease is related to cholinergic system degeneration,
which can be assessed in vivo using structural MRI markers of basal forebrain volume and …

Background Severe cholinergic degeneration is known to occur in Parkinson's disease (PD)
and is thought to play a primary role in the cognitive decline associated with this disease …

Abstract See Gratwicke and Foltynie (doi: 10.1093/brain/awx333) for a scientific commentary
on this article. Cognitive impairments are a prevalent and disabling non-motor complication …

Objective A major contributor to dementia in Parkinson disease (PD) is degeneration of the
cholinergic basal forebrain. This study determined whether cholinergic nucleus 4 (Ch4) …

Objectives Cholinergic dysfunction plays a prominent role in cognitive impairment in
Parkinson's disease (PD). The aim of this study was to assess the relationship of baseline …

Background: Cholinergic degeneration is strongly associated with cognitive decline in
patients with Parkinson's disease (PD) but may also cause motor symptoms and olfactory …

Cortical cholinergic deficits contribute to cognitive decline and other deficits in Parkinson's
disease. Cross-sectional imaging studies suggest a stereotyped pattern of posterior-to …

Objectives Structural imaging of the cholinergic basal forebrain may provide a biomarker for
cholinergic system integrity that can be used in motor and non‐motor outcome studies in …

Introduction We aimed to assess associations between multimodal neuroimaging measures
of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) …

Most individuals with Parkinson's disease experience cognitive decline. Mounting evidence
suggests this is partially caused by cholinergic denervation due to α-synuclein pathology in …