Inhalation of antiviral drugs to combat respiratory virus infections: broadening the horizon in times of pandemic pressure

R Heida - 2024 - research.rug.nl
The COVID-19 pandemic has underlined the threat that viral outbreaks can pose to human
health. Therefore, it is essential to have high-quality antiviral drugs available that can be …

Treatment of respiratory viral infections through inhalation therapeutics: Challenges and opportunities

N Nainwal - Pulmonary Pharmacology & Therapeutics, 2022 - Elsevier
Respiratory viral infections are the leading cause of death worldwide. The current pandemic
of coronavirus infection (COVID-19) challenged human beings for the treatment and …

Antivirals and the potential benefits of orally inhaled drug administration in COVID-19 treatment

G Sahin, O Akbal-Dagistan, M Culha, A Erturk… - Journal of …, 2022 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) pandemic has been on the agenda of
humanity for more than 2 years. In the meantime, the pandemic has caused economic …

Inhaled therapy for COVID-19: considerations of drugs, formulations and devices

T Saha, ME Quiñones-Mateu, SC Das - International Journal of …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent
responsible for the COVID-19 pandemic, has outspread at full tilt across the world. Although …

Therapeutic potential of inhalable medications to combat coronavirus disease-2019

V Parvathaneni, NS Kulkarni, A Muth… - Therapeutic …, 2021 - Taylor & Francis
The recent outbreak of coronavirus disease-2019 (COVID-19) in Wuhan, China has rapidly
spread across the world. The swift development of this pandemic has been attributed to …

[PDF][PDF] Lung Delivery Systems to Optimize Pharmacotherapy of COVID-19: A Concise Review

MG Alrashedi, AG Alrashedi, AS Ali… - J. Pharm. Res. Int, 2021 - researchgate.net
Background: COVID-19 is an ongoing viral pandemic caused by the SARS-COV-2 virus.
Several drugs were repurposed for its management; however, most of these drugs were not …

Inhaled dry powder to treat respiratory infections

T Saha - 2024 - ourarchive.otago.ac.nz
Abstract Respiratory Infections SARS-CoV-2 COVID-19 Dry powder inhaler Repurposed
drugs Spray drying Anti-viral nti-microbial Anti-infective Anti-SARS-CoV-2 Cytotoxicity Drug …

Recent advances in inhaled nanoformulations of vaccines and therapeutics targeting respiratory viral infections

CY Loo, WH Lee, QT Zhou - Pharmaceutical research, 2023 - Springer
With the rapid outbreak of respiratory viral infections, various biological (eg vaccines,
peptides, recombinant proteins, antibodies and genes) and antiviral agents (eg ribavirin …

The in vivo antiviral efficacy of a novel inhalation drug candidate in a mouse treatment and post-exposure prophylaxis model

J Zhou, E Jørgensen, JP Christensen, MTD Le… - 2023 - Eur Respiratory Soc
Background: Hypochlorous acid (HOCl), which is produced endogenously by neutrophils
and other phagocytes, has shown efficacy against a wide range of pathogens in vitro. The …

Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administration

R Heida, HW Frijlink, WLJ Hinrichs - Mbio, 2023 - Am Soc Microbiol
Many of the current pandemic threats are caused by viruses that infect the respiratory tract.
Remarkably though, the majority of vaccines and antiviral drugs are administered via …