Target protection proteins confer resistance to the host organism by directly binding to the
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …

Several ATPases in the ATP-binding cassette F (ABCF) family confer resistance to
macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct …

Members of the ATP‐binding cassette F (ABC‐F) proteins confer resistance to several
classes of clinically important antibiotics through ribosome protection. Recent structures of …

Many Gram-positive pathogenic bacteria employ ribosomal protection proteins (RPPs) to
confer resistance to clinically important antibiotics. In Bacillus subtilis, the RPP VmlR confers …

Members of the ATP-binding cassette (ABC)-F protein subfamily collectively mediate
resistance to a broader range of clinically important antibiotic classes than any other group …

Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a
broad array of clinically important antibiotic classes that target the ribosome of Gram-positive …

The first member of the pleuromutilin (PLM) class suitable for systemic antibacterial
chemotherapy in humans recently entered clinical use, underscoring the need to better …

The increase in multidrug-resistant pathogenic bacteria is limiting the utility of our current
arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain …

The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance
is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer …

A ntibiotic r esistance ABC-Fs (ARE ABC-Fs) are translation factors that provide resistance
against clinically important ribosome-targeting antibiotics which are proliferating among …