[PDF][PDF] Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs
VV Ignatova, P Stolz, S Kaiser… - Genes & …, 2020 - genesdev.cshlp.org
Covalent chemical modifications of cellular RNAs directly impact all biological processes.
However, our mechanistic understanding of the enzymes catalyzing these modifications …
However, our mechanistic understanding of the enzymes catalyzing these modifications …
Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
X Liu, H Wang, X Zhao, Q Luo, Q Wang, K Tan… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …
mRNAs, plays key roles in human development and health. Post-translational methylation of …
m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region
Abstract The N6‐methyladenosine (m6A) RNA modification serves crucial functions in RNA
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …
Mettl14 is required for mouse post-implantation development by facilitating epiblast maturation
TG Meng, X Lu, L Guo, GM Hou, XS Ma, QN Li… - bioRxiv, 2018 - biorxiv.org
ABSTRACT N6-methyladenosine (m6A) is the most prevalent and reversible internal
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA
N 6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes
degradation of transcripts encoding proteins that have roles in cell development …
degradation of transcripts encoding proteins that have roles in cell development …
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant internal
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
Acute depletion of METTL3 implicates N6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
RNA N 6-methyladenosine (m6A) modification plays important roles in multiple aspects of
RNA regulation. m6A is installed cotranscriptionally by the METTL3/14 complex, but its direct …
RNA regulation. m6A is installed cotranscriptionally by the METTL3/14 complex, but its direct …