[HTML][HTML] Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

TA Seimon, MJ Nadolski, X Liao, J Magallon… - Cell metabolism, 2010 - cell.com
Macrophage apoptosis in advanced atheromata, a key process in plaque necrosis, involves
the combination of ER stress with other proapoptotic stimuli. We show here that oxidized …

Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress

I Tabas - Antioxidants & redox signaling, 2009 - liebertpub.com
Atherothrombotic vascular diseases, such as myocardial infarction and stroke, are the
leading causes of death in the industrialized world. The immediate cause of these diseases …

Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced …

WS Lim, JM Timmins, TA Seimon, A Sadler… - Circulation, 2008 - Am Heart Assoc
Background—Macrophage apoptosis is a critical process in the formation of necrotic cores
in vulnerable atherosclerotic plaques. In vitro and in vivo data suggest that macrophage …

[HTML][HTML] Mechanisms and consequences of macrophage apoptosis in atherosclerosis

T Seimon, I Tabas - Journal of lipid research, 2009 - ASBMB
Macrophage apoptosis is an important feature of atherosclerotic plaque development.
Research directed at understanding the functional consequences of macrophage death in …

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

T DeVries-Seimon, Y Li, PM Yao, E Stone… - The Journal of cell …, 2005 - rupress.org
Macrophage death in advanced atherosclerosis promotes necrosis and plaque
destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) …

Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation

PG Yancey, J Blakemore, L Ding, D Fan… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—The balance between apoptosis susceptibility and efferocytosis of macrophages
is central to plaque remodeling and inflammation. LRP-1 and its ligand, apolipoprotein E …

Apoptosis induced by oxidized low density lipoprotein in human monocyte‐derived macrophages involves CD36 and activation of caspase‐3

ES Wintergerst, J Jelk, C Rahner… - European Journal of …, 2000 - Wiley Online Library
Macrophage death may play a crucial role in the progression of atherosclerotic lesions. Here
we present evidence that CD36 is involved in oxidized LDL (OxLDL)‐induced apoptosis in …

Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress–mediated apoptosis

EK Anderson, AA Hill, AH Hasty - Arteriosclerosis, thrombosis, and …, 2012 - Am Heart Assoc
Objective—Elevated serum free fatty acid levels are associated with an increased risk of
cardiovascular disease and type 2 diabetes mellitus. Macrophages are recruited to …

Macrophage apoptosis in advanced atherosclerosis

I Tabas, T Seimon, J Timmins, G Li… - Annals of the New York …, 2009 - Wiley Online Library
Plaque necrosis in advanced atheromata, which triggers acute atherothrombotic vascular
events, is caused by the apoptosis of lesional macrophages coupled with defective …

Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice

J Liu, DP Thewke, YR Su, MRF Linton… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—The majority of apoptotic cells in atherosclerotic lesions are macrophages.
However, the pathogenic role of macrophage apoptosis in the development of …