Publisher Summary The studies with novel P2 receptor agonists and antagonists point out
that the P2Y receptor in the taenia coli is different from the P2Y, receptor in turkey …

Since the beginning of purinoceptor research turkey erythrocytes have been widely used as
the model systems for studying the pharmacology of P2Y1 nucleotide receptors. In this …

P2Y1 receptors are activated by ADP and occur on endothelial cells, smooth muscle,
epithelial cells, lungs, pancreas, platelets, and in the central nervous system. With the aid of …

Purinergic signalling plays a crucial role in proper functioning of the nervous system.
Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a …

Binding of the radioligand [35 S] adenosine 5′-O-(2-thiodiphosphate)(ADPβ 35 S) to P 2y
purinoceptors on turkey erythrocyte membranes was used to determine the affinity of …

P2-receptors are widespread in animal and human organs and tissues. Therefore, they
attract much attention as potential targets of new drugs. This article presents in brief …

Although P2 receptors mediate a myriad of physiological effects of extracellular adenine
nucleotides, study of this broad class of receptors has been compromised by a lack of P2 …

Abstract Structure‐activity relationships (SAR) at P2 receptors that support their
subclassification into at least five nucleotide receptor subtypes, P2Z, P2T, P2Y, P2U, and …

The effects of structural modifications of adenine nucleotides previously shown to enhance
either agonist (2‐thioether groups) or antagonist (additional phosphate moieties at the 3 …

The P2Y1 receptor is present in the heart, in skeletal and various smooth muscles, and in
platelets, where its activation is linked to aggregation. Adenosine 3 ', 5 '-and 2 ', 5 ' …