Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple
sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on …

The objective of this study was to determine whether autoreactive T cells in patients with
multiple sclerosis (MS) are polarized and committed in their differentiation to a stable …

Multiple sclerosis (MS) is thought to be an autoimmune disorder. It is believed that
immunological events in the early stages have great impact on the disease course …

Myelin basic protein (MBP)‐reactive T cells have been implicated in the autoimmune
pathogenesis of multiple sclerosis (MS). In this study, we examined the cytokine profile of …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a
presumed autoimmune pathogenesis involving autoantigen-specific CD4+ T cells and …

Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis
(MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4+ …

Multiple sclerosis has been postulated to be an autoimmune disease in which Th1 immune
responses predominate. This response is associated with an increased production of IFNγ …

Myelin proteins, including myelin basic protein (MBP), proteolipid protein (PLP) and myelin
oligodendrocyte glycoprotein (MOG) are candidate autoantigens in MS. It is not clear …

Relapsing–remitting multiple sclerosis (RRMS) is a complex autoimmune disease of the
central nervous system with oscillating phases of relapse and remission. RRMS has been …

T cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis
of multiple sclerosis (MS). In this study, we demonstrated that subcutaneous inoculations …