Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse
cellular processes including cell death/survival, inflammation, iron delivery and cell …

ABSTRACT LCN2/neutrophil gelatinase-associated lipocalin/24p3 (lipocalin 2) is a
secretory protein that acts as a mammalian bacteriostatic molecule. Under …

Abstract Lipocalin-2 (LCN2) is a member of the secreted lipocalin protein family. LCN2 is
also a representative gliocalin that is primarily released by glial cells, as well as acts upon …

Background Functions of astrocytes in the rehabilitation after ischemic stroke, especially
their impacts on inflammatory processes, remain controversial. This study uncovered two …

ABSTRACT Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes
such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery …

Glial cell activation precedes neuronal cell death during brain aging and the progression of
neurodegenerative diseases. Under neuroinflammatory stress conditions, lipocalin-2 …

Background Reactive oxygen species (ROS) often promote acute brain injury after stroke,
but their roles in the recovery phase have not been well studied. We tested the hypothesis …

Stroke is a common and devastating disease with an escalating prevalence worldwide. The
known secondary injuries after stroke include cell death, neuroinflammation, blood-brain …

Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. In response to a brain injury, astrocytes …

Reactive glial cells are hallmarks of brain injury. However, whether these cells contribute to
secondary inflammatory pathology and neurological deficits remains poorly understood …