The Sertoli cells are critical regulators of testis differentiation and development. In the adult,
however, their known function is restricted largely to maintenance of spermatogenesis. To …

Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main
regulators of spermatogenesis in the adult testis; however, their role during the intervening …

Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

Disorders of testicular function may have their origins in fetal or early life as a result of
abnormal development or proliferation of Sertoli cells. Failure of Sertoli cells to mature, with …

Sertoli cells regulate differentiation and development of the testis and are essential for
maintaining adult testis function. To model the effects of dysregulating Sertoli cell number …

Peritubular myoid (PM) cells surround the seminiferous tubule and together with Sertoli cells
form the cellular boundary of the spermatogonial stem cell (SSC) niche. However, it remains …

The testis is an endocrine-responsive tissue that requires a number of important cell-cell
interactions for the maintenance and control of cellular growth and differentiation. The Sertoli …

A healthy man typically produces between 50× 10 6 and 200× 10 6 spermatozoa per day by
spermatogenesis; in the absence of Sertoli cells in the male gonad, this individual would be …

Androgens are essential for normal spermatogenesis and male fertility, but how androgens
exert this effect remains uncertain. Androgen receptors (ARs) are expressed in several …

Spermatogenesis is fundamental to the establishment and maintenance of male
reproduction, whereas its abnormality results in male infertility. Somatic cells, including …