BACKGROUND We have shown elevated levels of p53 and active caspase-3 in the heart
with Parkinson disease (PD). The main aim of this study is to examine the effect of treadmill …

BACKGROUND: We have shown elevated levels of p53 and active caspase-3 in
gastrocnemius skeletal muscle with Parkinson's disease (PD). The main aim of this study is …

Background Apoptosis plays a key role in the pathogenesis of Parkinson disease (PD).
Active caspase-3, which is a proapoptotic factor, has been shown to reduce cardiac …

Apoptosis has been implicated in the pathogenesis of Parkinson disease (PD). Parkinson
disease is characterized by skeletal muscle abnormalities. The aim of this study is to …

Abstract Background Animal models of Parkinson's disease have been widely used for
investigating the mechanisms of neurodegenerative process and for discovering alternative …

Background The incidence and prevalence of heart failure increases with age.
Cardiomyocyte apoptosis contributes to the pathogenesis of heart failure. In the end-stage of …

BACKGROUND: Induction of Parkinson disease (PD) causes interleukin-1 beta (IL-1β) and
tumor necrosis factor-alpha (TNF-α) upregulation in gastrocnemius skeletal muscles …

The etiology of neurodegenerative disorders like Parkinson's disease remains unknown,
although many genetic and environmental factors are suggested as likely causes. Neuronal …

AIMS: Parkinson's disease is a debilitating neurodegenerative disorder characterized by the
gradual loss of dopaminergic neurons. We investigated the effects of treadmill exercise on …

[Purpose] We investigated whether treadmill exercise (TE)-induced neuroprotection was
associated with enhanced autophagy and reduced apoptosis in a mouse model of …