Background Colorectal tumors caused by failure of the DNA mismatch repair system
commonly show microsatellite instability. Our goals were to compare the performance of two …

Purpose: Microsatellite instability (MSI) is found in 10% to 15% of sporadic colorectal tumors
and is usually caused by defects in DNA mismatch repair (MMR). In 1997, a panel of …

PURPOSE: To compare microsatellite instability (MSI) testing with immunohistochemical
(IHC) detection of hMLH1 and hMSH2 in colorectal cancer. PATIENTS AND METHODS …

Tumour microsatellite instability (MSI) is useful in identifying patients with hereditary non-
polyposis colorectal cancer (HNPCC) with defective DNA mismatch repair (MMR) genes. A …

Two types of molecular tests have been established to assess the deficiency of the DNA
mismatch repair (MMR) system: microsatellite instability (MSI) and immunohistochemical …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

Microsatellite instability is associated with 10% to 15% of colorectal, endometrial, ovarian,
and gastric cancers, and has long been used as a diagnostic tool for hereditary …

Alterations of the length of simple repetitive genomic sequences (microsatellite instability,
MSI) characterize a distinct mechanism of colorectal carcinogenesis. Such MSI has been …

Microsatellite instability (MSI) analysis of colorectal cancers is clinically useful to identify
patients with hereditary nonpolyposis colorectal cancer (HNPCC) caused by germline …

The detection of defective mismatch repair (MMR), as assessed by the presence of tumor
microsatellite instability (MSI) and/or loss of MMR protein expression by IHC, has been …