Cavernous Nerve Injury by Radiotherapy Potentiates Erectile Dysfunction in Rats

C Connors - 2017 - search.proquest.com
Approximately 50% of prostate cancer patients receiving radiotherapy develop erectile
dysfunction within 3–5 years. The precise role of radiation-induced neurogenic injury post …

Cavernous nerve injury by radiation therapy may potentiate erectile dysfunction in rats

J Mahmood, CQ Connors, AA Alexander… - International Journal of …, 2017 - Elsevier
Purpose/Objectives Radiation-induced erectile-dysfunction (RiED) is one of the most
common side effects of radiation therapy (RT) and significantly reduces the quality of life …

RhoA/ROCK pathway inhibitor ameliorates erectile dysfunction induced by radiation therapy in rats

J Mahmood, R Pandita, A Zhang, S Kamlapurkar… - Radiotherapy and …, 2020 - Elsevier
Abstract Objectives Prostate cancer (PCa) treatment with radiation therapy (RT) has an
excellent cure rate. However, Radiation-induced Erectile Dysfunction (RiED) is a common …

Elucidation of the Molecular Mechanism of Radiation-Induced Erectile Dysfunction

J Mahmood, AA Shamah, M Creed… - International Journal of …, 2016 - redjournal.org
Results ICP measurements were conducted in order to analyze nerve-mediated penile
erection. There was a significant (P< 0.001) reduction of ICP/MAP ratio in RT rats compared …

Prostate-confined radiation decreased pelvic ganglia neuronal survival and outgrowth

SA Powers, MR Odom, ES Pak… - The Journal of …, 2019 - academic.oup.com
Background Erectile dysfunction (ED) is common following radiation therapy (RT) for
prostate cancer. Although the cause of RT-induced ED is unknown, damage to both the …

Radiation‐induced erectile dysfunction using prostate‐confined modern radiotherapy in a rat model

M Kimura, H Yan, Z Rabbani, T Satoh… - The journal of sexual …, 2011 - academic.oup.com
Introduction The mechanisms of radiation‐induced erectile dysfunction (ED) are unclear, as
clinical studies are limited, and previous animal models were based on wide‐field …

[HTML][HTML] Radiation-induced erectile dysfunction: Recent advances and future directions

J Mahmood, AA Shamah, TM Creed, R Pavlovic… - Advances in radiation …, 2016 - Elsevier
Prostate cancer is one of the most prevalent cancers and the second leading cause of
cancer-related deaths in men in the United States. A large number of patients undergo …

Pudendal nerve and internal pudendal artery damage may contribute to radiation-induced erectile dysfunction

MW Nolan, AJ Marolf, EJ Ehrhart, S Rao… - International Journal of …, 2015 - Elsevier
Purpose/Objectives Erectile dysfunction is common after radiation therapy for prostate
cancer; yet, the etiopathology of radiation-induced erectile dysfunction (RI-ED) remains …

Impact of prostate cancer treatment on pelvic nerve injury and erectile function

SA Powers - 2018 - thescholarship.ecu.edu
Following prostate cancer treatment, many men will experience urogenital side effects
including erectile dysfunction (ED), a condition significantly affecting survivor quality of life …

Etiology of Radiation-Induced Erectile Dysfunction: Vessel or Nerve?

BF Koontz, K Ashcraft, A Faught, P Patel… - International Journal of …, 2016 - redjournal.org
Results RT significantly impaired the vasodilatory response to hydralazine which was
protected by VRA (change in IPA diameter+ 28% for sham/saline,-7.4% for RT/saline,+ 24 …