MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target
A majority, if not all, acute and progressive neurodegenerative diseases are accompanied
by local microglia‐mediated inflammation, astrogliosis, infiltration of immune cells, and …
by local microglia‐mediated inflammation, astrogliosis, infiltration of immune cells, and …
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
B Kaminska - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation
K Biswas - Journal of Neuroimmunology, 2023 - Elsevier
Microglia, the immune sentinels of the central nervous system (CNS), have emerged to be
the central players in many neurological and neurodegenerative diseases. Recent studies …
the central players in many neurological and neurodegenerative diseases. Recent studies …
[HTML][HTML] Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation
B Kaminska, M Mota, M Pizzi - … et Biophysica Acta (BBA)-Molecular Basis of …, 2016 - Elsevier
Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …
[HTML][HTML] Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation
Microglia are integral mediators of innate immunity within the mammalian central nervous
system. Typical microglial responses are transient, intending to restore homeostasis by …
system. Typical microglial responses are transient, intending to restore homeostasis by …
Role of microglia in neurological disorders and their potentials as a therapeutic target
L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …
and play a vital role in both physiological and pathological conditions, including restoring …
Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies
N Gupta, S Shyamasundar, R Patnala… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Chronic activation of microglia is the hallmark of numerous neuropathologies
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …
Role of microglia in neuronal degeneration and regeneration
Microglial cells, the resident macrophage population of the central nervous system (CNS),
actively scan tissue under both normal and pathologic contexts. Their resulting engagement …
actively scan tissue under both normal and pathologic contexts. Their resulting engagement …
[HTML][HTML] Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response
S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
The yin and yang of microglia
M Czeh, P Gressens, AM Kaindl - Developmental neuroscience, 2011 - karger.com
Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a
pivotal role in both physiological and pathological conditions such as the restoration of CNS …
pivotal role in both physiological and pathological conditions such as the restoration of CNS …