MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target

B Kaminska, A Gozdz, M Zawadzka… - … Record: Advances in …, 2009 - Wiley Online Library
A majority, if not all, acute and progressive neurodegenerative diseases are accompanied
by local microglia‐mediated inflammation, astrogliosis, infiltration of immune cells, and …

MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits

B Kaminska - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation

K Biswas - Journal of Neuroimmunology, 2023 - Elsevier
Microglia, the immune sentinels of the central nervous system (CNS), have emerged to be
the central players in many neurological and neurodegenerative diseases. Recent studies …

[HTML][HTML] Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation

B Kaminska, M Mota, M Pizzi - … et Biophysica Acta (BBA)-Molecular Basis of …, 2016 - Elsevier
Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …

[HTML][HTML] Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

E Chu, R Mychasiuk, ML Hibbs, BD Semple - Journal of …, 2021 - Springer
Microglia are integral mediators of innate immunity within the mammalian central nervous
system. Typical microglial responses are transient, intending to restore homeostasis by …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies

N Gupta, S Shyamasundar, R Patnala… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Chronic activation of microglia is the hallmark of numerous neuropathologies
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …

Role of microglia in neuronal degeneration and regeneration

L Walter, H Neumann - Seminars in immunopathology, 2009 - Springer
Microglial cells, the resident macrophage population of the central nervous system (CNS),
actively scan tissue under both normal and pathologic contexts. Their resulting engagement …

[HTML][HTML] Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response

S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

The yin and yang of microglia

M Czeh, P Gressens, AM Kaindl - Developmental neuroscience, 2011 - karger.com
Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a
pivotal role in both physiological and pathological conditions such as the restoration of CNS …