This study assessed behavioural and neurochemical effects of icv injections of both the
cholinergic toxin 192 IgG‐saporin (2 μg) and the serotonergic toxin 5, 7‐dihydroxytryptamine …

In a previous experiment [Eur J Neurosci 12 (2000) 79], combined intracerebroventricular
injections of 5, 7-dihydroxytryptamine (5, 7-DHT; 150 μg) and 192 IgG-saporin (2 μg) in …

The elucidation of the functional role of the basal forebrain cholinergic system will require
access to a highly specific and efficient cholinergic neurotoxin. Recently, selective depletion …

Abstract Adult Long–Evans male rats sustained injections of 5, 7‐dihydroxytryptamine into
the fimbria–fornix (2.5 µg/side) and the cingular bundle (1.5 µg/side) and/or to intraseptal …

Abstract The effect of (+)-amphetamine and (±) p-chloroamphetamine on the levels of
choline and acetylcholine (ACh) in discrete regions of rat brain were studied. Animals were …

A novel cholinergic immunotoxin (conjugate of the monoclonal antibody 192IgG against the
low-affinity nerve growth factor receptor with the cytotoxin saporin) producing selective …

Impairment of the basal forebrain cholinergic system is an important change in the brains of
Alzheimer's disease patients. Various neurotoxins have been used to achieve this in animal …

A complete and selective destruction of the basal forebrain cholinergic neurons projecting to
the cerebral cortex and the hippocampus was induced in the rat by the toxin 192 IgG …

The behavioral, biochemical, histological, and electrophysiological effects of a basal
forebrain injection of saporin, a ribosome-inactivating protein, coupled to a monoclonal …

To lesion the cholinergic input to the hippocampus, rats received injections of 192 IgG‐
saporin into the medial septum/vertical limb of the diagonal band (MS/VDB). The lesions …