Effect of varying the molecular weight of the MR contrast agent Gd‐DTPA‐polylysine on blood pharmacokinetics and enhancement patterns

VS Vexler, O Clément… - Journal of Magnetic …, 1994 - Wiley Online Library
The effects of varying the molecular weight of gadolinium‐DTPA (
diethylenetriaminepentaacetic acid)—polylysine, a macromolecular magnetic resonance …

In vivo and in vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging

G SCHUHMANN-GIAMPIERI… - Investigative …, 1991 - journals.lww.com
Polylysine covalently linked to moieties of gadopentelate (Gd-DTPA), for use as a
macromolecular blood pool marker for contrast material-enhanced magnetic resonance …

NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat

P Van Hecke, G Marchal, H Bosmans… - Magnetic Resonance …, 1991 - Elsevier
The pharmacodynamics of polylysine-(Gd-DTPA)(Schering, Berlin, Germany), a new blood
pooling contrast agent for MRI, were studied in the rabbit and the rat. Polylysine-(Gd-DTPA) …

Gd‐DTPA‐cascade‐polymer: potential blood pool contrast agent for MR imaging

G Adam, J Neuerburg, E Spüntrup… - Journal of Magnetic …, 1994 - Wiley Online Library
Abstract Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a
potential new blood pool contrast agent for magnetic resonance (MR) imaging, was …

[引用][C] Rationale and applications for macromolecular Gd‐based contrast agents

RC Brasch - Magnetic resonance in medicine, 1991 - Wiley Online Library
Macromolecular contrast media (MMCM) for MRI may be defined as paramagnetic or
superparamagnetic compounds of sufficient molecular weight, generally> 20,000 daltons …

Dynamics of tumor imaging with Gd‐DTPA—polyethylene glycol polymers: Dependence on molecular weight

TS Desser, DL Rubin, HH Muller, F Qing… - Journal of Magnetic …, 1994 - Wiley Online Library
Macromolecular contrast media offer potential advantages over freely diffusible agents in
magnetic resonance (MR) imaging outside the central nervous system. To identify an …

Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: and experimental study in rats

U Schmiedl, MD Ogan, ME Moseley… - American journal of …, 1986 - Am Roentgen Ray Soc
Albumin-(gadolinium-diethylenetriaminepentaacetic acid), albumin-(Gd-DTPA), a
macromolecular MR contrast agent designed for intravascular distribution, was compared …

Capillary leakage of a macromolecular MRI agent, carboxymethyldextran-Gd-DTPA, in the liver: pharmacokinetics and imaging implications

N Siauve, O Clément, CA Cuénod… - Magnetic resonance …, 1996 - Elsevier
Capillary leakage of a macromolecular contrast agent, Carboxymethyl Dextran-Gd-DTPA
(CMD-Gd-DTPA) was characterized in a highly permeable system, the liver, to assess its …

Gadolinium-containing copolymeric chelates—a new potential MR contrast agent

EC Unger, D Shen, G Wu, L Stewart… - … Resonance Materials in …, 1999 - Springer
Rationale and objectives: To develop and partially characterize a new class of potential
blood pool magnetic resonance (MR) contrast agents. Methods: Various copolymeric …

Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent

X Wang, Y Feng, T Ke, M Schabel, ZR Lu - Pharmaceutical research, 2005 - Springer
No Heading Purpose. To investigate the pharmacokinetics, long-term tissue retention of Gd
(III) ions, and magnetic resonance imaging (MRI) contrast enhancement of extracellular …