Background Heat shock protein 90 (HSP90) is an important chaperone supporting the
function of many proinflammatory client proteins. Recent studies indicate HSP90 inhibition …

Introduction Chronic inflammatory skin diseases may have a profound negative impact on
the quality of life. Current treatment options may be inadequate, offering an unsatisfactory …

Molecular chaperones belonging to the heat shock protein 90 (Hsp90) family are implicated
in inflammatory processes and described as potential novel therapeutic targets in …

Heat shock proteins (Hsp) are constitutive and stress-induced molecules which have been
reported to impact innate and adaptive immune responses. Here, we evaluated the role of …

Keratinocytes are the key cellular target for IL‐17A‐mediated effects in psoriasis and HSP90
is important for IL‐17A‐mediated signalling. RGRN‐305 is a novel HSP90 inhibitor reported …

Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential
genetic etiology. The newest treatments utilize antibodies against one of several cytokines …

Abstract Heat shock protein 60 (hsp60) is a highly conserved stress protein and target of self-
reactive T cells in various inflammatory diseases. Not much is known about a possible role …

Background Atopic dermatitis is a chronic, relapsing inflammatory disease of the skin.
Current therapy is not curative, and recalcitrant disease is a big stress and challenge for …

Atopic dermatitis (AD) is one of the most common chronic inflammatory dermatoses
characterized by persistent itching and recurrent eczematous lesions. While the primary …

Background Psoriasis is a chronic inflammatory skin disease and various stress factors
mediate inflammation. Heat shock protein (HSP) 90 plays an important role in cell survival; …