Genetics of the variable expression of CYP3A in humans
L Wojnowski - Therapeutic drug monitoring, 2004 - journals.lww.com
CYP3A isozymes participate in the metabolism of 45–60% of currently used drugs and of a
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …
Genetic contribution to variable human CYP3A-mediated metabolism
The human CYP3A subfamily plays a dominant role in the metabolic elimination of more
drugs than any other biotransformation enzyme. CYP3A enzyme is localized in the liver and …
drugs than any other biotransformation enzyme. CYP3A enzyme is localized in the liver and …
Identification and functional characterization of eight CYP3A4 protein variants
R Eiselt, TL Domanski, A Zibat, R Mueller… - Pharmacogenetics …, 2001 - journals.lww.com
The genetic component of the inter-individual variability in CYP3A4 activity has been
estimated to be between 60% and 90%, but the underlying genetic factors remain largely …
estimated to be between 60% and 90%, but the underlying genetic factors remain largely …
Cytochrome P450 3A and their regulation
O Burk, L Wojnowski - Naunyn-Schmiedeberg's archives of pharmacology, 2004 - Springer
CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
CYP3A5 Variant Allele Frequencies in Dutch Caucasians
RHN van Schaik, IP van der Heiden… - Clinical …, 2002 - academic.oup.com
Background: Enzymes of the cytochrome P450 3A (CYP3A) family are responsible for the
metabolism of> 50% of currently prescribed drugs. CYP3A5 is expressed in a limited …
metabolism of> 50% of currently prescribed drugs. CYP3A5 is expressed in a limited …
Clinical implications of CYP3A polymorphisms
L Wojnowski, LK Kamdem - Expert Opinion On Drug Metabolism & …, 2006 - Taylor & Francis
Due to their enormous substrate spectrum CYP3A4,-3A5 and-3A7 constitute the most
important drug-metabolising enzyme subfamily in humans. CYP3As are expressed …
important drug-metabolising enzyme subfamily in humans. CYP3As are expressed …
Genetic variability in CYP3A5 and its possible consequences
The cytochrome P450 3A (CYP3A) subfamily members are the most abundant and important
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene
K Gellner, R Eiselt, E Hustert, H Arnold… - Pharmacogenetics …, 2001 - journals.lww.com
Proteins encoded by the human CYP3A genes metabolize every second drug currently in
use. The activity of CYP3A gene products in the general population is highly variable and …
use. The activity of CYP3A gene products in the general population is highly variable and …
Functionally Defective or Altered CYP3A4 and CYP3A5 Single Nucleotide Polymorphisms and Their Detection with Genotyping Tests
SJ Lee, JA Goldstein - Pharmacogenomics, 2005 - Taylor & Francis
Among the four cytochrome P450 (CYP) 3A genes, CYP3A4 and CYP3A5 are the most
abundantly expressed in the human liver. Eighty single nucleotide polymorphisms (SNPs) of …
abundantly expressed in the human liver. Eighty single nucleotide polymorphisms (SNPs) of …
Lessons from the CYP3A4 promoter
EG Schuetz - Molecular pharmacology, 2004 - ASPET
There is considerable interest in determining the molecular basis for human variation in drug
response. Investigations over the past 20 years have largely focused on identifying …
response. Investigations over the past 20 years have largely focused on identifying …