Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

The identification of conserved autophagy-related proteins (ATGs) that mediate bulk
degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to …

Autophagy is a fundamental catabolic process that uses a unique post-translational
modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). ATG8 …

Non-canonical autophagy is a key cellular pathway in immunity, cancer, and
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …

Autophagy (literally 'self‐eating') is an evolutionarily conserved degradation process where
cytoplasmic components are engulfed by vesicles called autophagosomes, which are then …

Autophagy is a potent cellular degradation pathway, and its activation needs to be tightly
controlled. Cargo receptors mediate selectivity during autophagy by bringing cargo to the …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Autophagy recycles cytoplasmic components by sequestering them in double membrane–
surrounded autophagosomes. The two proteins Atg11 and Atg17 are scaffolding …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved
intracellular catabolic transport route that generally allows the lysosomal degradation of …