Evidence of the Involvement of a Cyclase Gene in the Biosynthesis of Ochratoxin A in Aspergillus carbonarius

M Ferrara, A Gallo, C Cervini, L Gambacorta… - Toxins, 2021 - mdpi.com
Ochratoxin A (OTA) is a well-known mycotoxin with wide distribution in food and feed.
Fungal genome sequencing has great utility for identifying secondary metabolites gene …

Comparative genomic analysis of ochratoxin A biosynthetic cluster in producing fungi: New evidence of a cyclase gene involvement

M Ferrara, A Gallo, G Perrone, D Magistà… - Frontiers in …, 2020 - frontiersin.org
The widespread use of Next-Generation Sequencing has opened a new era in the study of
biological systems by significantly increasing the catalog of fungal genomes sequences and …

The Genomic Regions That Contain Ochratoxin A Biosynthetic Genes Widely Differ in Aspergillus Section Circumdati Species

J Gil-Serna, C Vázquez, B Patiño - Toxins, 2020 - mdpi.com
Aspergillus section Circumdati includes 27 species, some of which are considered
ochratoxin A (OTA) producers. However, there is considerable controversy about their …

Molecular characterization of ochratoxin A biosynthesis and producing fungi

J O'callaghan, ADW Dobson - Advances in applied microbiology, 2005 - Elsevier
Publisher Summary This chapter discusses the molecular characterization of ochratoxin.
Ochratoxin A (OTA) is a fungal secondary metabolite consisting of a polyketide derived from …

A consensus ochratoxin A biosynthetic pathway: Insights from the genome sequence of Aspergillus ochraceus and a comparative genomic analysis

Y Wang, L Wang, F Wu, F Liu, Q Wang… - Applied and …, 2018 - Am Soc Microbiol
Ochratoxin A (OTA) is a toxic secondary metabolite produced by Aspergillus and Penicillium
species that widely contaminates food and feed. We sequenced and assembled the …

Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis

J Gil-Serna, M García-Díaz, MT González-Jaén… - International journal of …, 2018 - Elsevier
Ochratoxin A (OTA) is one of the most important mycotoxins due to its toxic properties and
worldwide distribution which is produced by several Aspergillus and Penicillium species …

Clustered array of ochratoxin A biosynthetic genes in Aspergillus steynii and their expression patterns in permissive conditions

J Gil-Serna, C Vázquez, MT González-Jaén… - International Journal of …, 2015 - Elsevier
Aspergillus steynii is probably the most relevant species of section Circumdati producing
ochratoxin A (OTA). This mycotoxin contaminates a wide number of commodities and it is …

Ochratoxin A biosynthetic genes in Aspergillus ochraceus are differentially regulated by pH and nutritional stimuli

J O'Callaghan, PC Stapleton, ADW Dobson - Fungal Genetics and Biology, 2006 - Elsevier
Expression of the polyketide synthase (pks) gene which is involved in ochratoxin A (OTA)
biosynthesis in Aspergillus ochraceus is linked to production of the mycotoxin, with high …

Identification of a halogenase involved in the biosynthesis of ochratoxin A in Aspergillus carbonarius

M Ferrara, G Perrone, L Gambacorta… - Applied and …, 2016 - Am Soc Microbiol
Aspergillus carbonarius is the main responsible fungus of ochratoxin A (OTA) contamination
of grapes and derived products. To date, the biosynthetic mechanism of this mycotoxin has …

New insight into the ochratoxin A biosynthetic pathway through deletion of a nonribosomal peptide synthetase gene in Aspergillus carbonarius

A Gallo, KS Bruno, M Solfrizzo, G Perrone… - Applied and …, 2012 - Am Soc Microbiol
Ochratoxin A (OTA), a mycotoxin produced by Aspergillus and Penicillium species, is
composed of a dihydroisocoumarin ring linked to phenylalanine, and its biosynthetic …