Calcium flux into and out of the sarco (endo) plasmic reticulum is vitally important to cardiac
function because the cycle of calcium entry and exit controls contraction and relaxation …

Aims Sex differences have been consistently identified in cardiac physiology and incidence
of cardiac disease. However, the underlying biological causes for the differences remain …

The incidence and expression of cardiovascular diseases differs between the sexes. This is
not surprising, as cardiac physiology differs between men and women. Clinical and basic …

The incidence of cardiovascular disease rises dramatically with age in both men and
women. Because a woman's risk of cardiovascular disease rises markedly after the onset of …

Biological sex is an important modifier of physiology and influences pathobiology in many
diseases. While heart disease is the number one cause of death worldwide in both men and …

Background The contribution of glucocorticoids to sexual dimorphism in the heart is
essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of …

Testosterone may affect myocardial contractility since its deficiency decreases the
contraction and relaxation of the heart. Meanwhile, testosterone replacement therapy has …

Alterations in intracellular Ca2+ transients of cardiomyocytes in orchidectomized (ORX) rats
could be a cause of cardiac dysfunction in the hypogonadal condition. To investigate the …

Biological sex plays an important role in normal cardiac physiology as well as in the heart's
response to cardiac disease. Women generally have better cardiac function and survival …

Background Left ventricular (LV) diastolic dysfunction often precedes heart failure with
preserved ejection fraction, the dominant form of heart failure in postmenopausal women …