One of the major causes of morbidity and mortality worldwide is cardiac hypertrophy (CH),
which leads to heart failure. Sex differences in CH can be caused by sex hormones or their …

Background. Sirtuin 1 (SIRT1) is a member of the sirtuin family, which could activate cell
survival machinery and has been shown to be protective in regulation of heart function …

Background: Pathological cardiac hypertrophy induced by stresses such as aging and
neurohumoral activation is an independent risk factor for heart failure and is considered a …

Abstract Sirtuin3 (SIRT3), a class III histone deacetylase, is implicated in various
cardiovascular diseases as a novel therapeutic target. SIRT3 has been proven to be …

Abstract Sirtuin 3 (SIRT3) is a type III histone deacetylase that inhibits cardiac hypertrophy. It
is mainly localized in the mitochondria and is thus implicated in mitochondrial metabolism …

The activation of signal transducer and activator of transcription 3 (STAT3) is critical for the
development of cardiac hypertrophy and heart failure. Sirtuin 6 (SIRT6) protects …

Introduction: Silent information regulator 1 (SIRT1) has been extensively investigated in the
cardiovascular system and has been shown to play a pivotal role in mediating cell …

SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important
roles in regulating genomic stability, metabolism, stress response and aging. Our previous …

Calorie restriction is considered to be the best environmental intervention providing health
benefits to mammals. The underlying mechanism of this intervention seems to be controlled …

SIRT3 belongs to a highly conserved protein family of histone deacetylases and it is rich in
mitochondria. As acetyl-modification is one of the important post-translational modifications …