Abstract Sickle Cell Anemia (SCA) is a hereditary blood disorder characterized by the
presence of abnormal hemoglobin, leading to chronic hemolytic anemia, vaso-occlusive …

Sickle cell disease (SCD) stands as one of the most prevalent genetic disorders globally,
characterized by the abnormal hemoglobin S (HbS) leading to distorted erythrocyte …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal
hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not …

Sickle cell disease (SCD) is caused by a monogenic mutation of the β-globin gene and
affects millions of people worldwide. SCD is associated with sustained hemolytic anemia …

Chronic hemolysis in sickle cell disease (SCD) gives rise to intermittent vessel occlusion.
Recurrent ischemia-reperfusion generates high levels of reactive oxygen species (ROS) that …

The basic leucine zipper transcription factor nuclear factor (erythroid-derived 2)-like 2
(NRF2) plays a critical role in the cellular antioxidant response under oxidative stress …

Abstract Sickle Cell Disease (SCD) is a hereditary hemoglobinopathy characterized by the
aberrant hemoglobin S, resulting in the formation of sickle-shaped red blood cells and a …

Individuals with sickle cell disease have severe anemia due to the production of abnormal
hemoglobin S, chronic red blood cell hemolysis, and increased oxidative stress leading to …

Sickle cell disease (SCD) is a chronic hemolytic and systemic hypoxia condition with
constant oxidative stress and significant metabolic alterations. However, little is known about …

Sickle cell anemia (SCA) is a hereditary hemoglobinopathy characterized by the presence of
abnormal hemoglobin S (HbS), leading to the polymerization of red blood cells and the …