Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …

Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is
dependent on a variety of factors, eg complex size, complex stability, toxicity …

Chitosan is an attractive gene delivery vehicle, but the criteria and strategies for the design
of efficient chitosan gene delivery systems remain unclear. The purpose of this work was to …

Gene delivery can particularly be used for the treatment of diseases by the insertion of
genetic materials (DNA and RNA) into mammalian cells either to express new proteins or to …

Gene therapy is a promising strategy for treating challenging diseases. The successful
delivery of genes is a critical step for gene therapy. However, concerns about …

Background Chitosans of high molecular weights have emerged as efficient nonviral gene
delivery systems, but the properties and efficiency of well‐defined low molecular weight …

Non-viral vectors, including lipid-or polymer-based systems, have attracted much attention to
date as a gene delivery vehicle, due to safety issues with viral vectors. Chitosan, a naturally …

Chitosan possesses many characteristics of an ideal gene delivery system. However, the
transfection efficiency of conventional chitosans is generally found to be low. In this study …

Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …