Hormones regulate growth, development, metabolism, and other complex processes in
multicellular animals. For many years it has been suggested that hormones may also …

Multiple biological and environmental factors impact the life span of an organism. The
endocrine system is a highly integrated physiological system in mammals that regulates …

The past few decades have witnessed increasing research clarifying the role of endocrine
signaling in the regulation of aging in both vertebrates and invertebrates. Studies using the …

Over the past 15 years it has become clear that mutations in genes that regulate endocrine
signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine …

Hormonal signals can modulate lifespan and reproductive capacity across the animal
kingdom. The use of model organisms such as worms, flies and mice has been …

In the last two decades it has become clear that hormones and gene mutations in endocrine
signaling pathways can exert major effects on lifespan and related life history traits in worms …

A remarkable plasticity in life span has been uncovered in recent years, offering hope that
the basic mechanisms of aging and interventions that delay aging may be identified in the …

The phenome represents the observable properties of an organism that have developed
under the continued influences of both genome and environmental factors. Phenotypic …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …

The complex, highly integrative endocrine system regulates all aspects of somatic
maintenance and reproduction and has been widely implicated as an important determinant …