The diffusion of next-generation sequencing (NGS)-based approaches allows for the
identification of pathogenic mutations of cardiomyopathies and channelopathies in more …

Recent advances in next-genetic sequencing technology have facilitated an expansion in
the use of exome and genome sequencing in the research and clinical settings. While this …

Background Genetic heterogeneity is common in inherited cardiac diseases. Next-
generation sequencing gene panels are therefore suitable for genetic diagnosis. We …

Next-generation sequencing to identify genetic causes of car... : Current Opinion in
Cardiology Next-generation sequencing to identify genetic causes of cardiomyopathies …

Background and objective Molecular diagnosis in inherited cardiac diseases is challenging
because of the significant genetic and clinical heterogeneity. We present a detailed …

Background: Accurately determining variant pathogenicity is critical in the diagnosis of
cardiac channelopathies; however, it remains unknown how variant pathogenicity status …

Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …

The molecular millennium has bestowed researchers with the essential tools to identify the
underlying genetic substrates for thousands of genetic disorders, most of which are rare and …

Background Diagnostic testing for genetic cardiomyopathies has undergone dramatic
changes in the last decade with next generation sequencing (NGS) expanding the number …

Background—Cardiomyopathy is highly heritable but genetically diverse. At present, genetic
testing for cardiomyopathy uses targeted sequencing to simultaneously assess the coding …