Virological control by the CD4-binding site antibody N6 in simian-human immunodeficiency virus-infected rhesus monkeys
B Julg, A Pegu, P Abbink, J Liu, A Brinkman… - Journal of …, 2017 - Am Soc Microbiol
Passive immunotherapy against HIV-1 will most likely require broadly neutralizing
antibodies (bnAbs) with maximum breadth and potency to ensure therapeutic efficacy …
antibodies (bnAbs) with maximum breadth and potency to ensure therapeutic efficacy …
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope
(Env) glycoprotein with specific cell surface receptors. Protective antiviral antibodies …
(Env) glycoprotein with specific cell surface receptors. Protective antiviral antibodies …
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals
Monoclonal antibody 10-1074 targets the V3 glycan supersite on the HIV-1 envelope (Env)
protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here …
protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here …
[HTML][HTML] A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo
The CD4 binding site (CD4bs) on the envelope glycoprotein is a major site of vulnerability
that is conserved among different HIV-1 isolates. Many broadly neutralizing antibodies …
that is conserved among different HIV-1 isolates. Many broadly neutralizing antibodies …
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes
The isolation of broadly neutralizing HIV-1 monoclonal antibodies (MAbs) to distinct
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
Over the past 5 years, a new generation of highly potent and broadly neutralizing HIV-1
antibodies has been identified. These antibodies can protect against lentiviral infection in …
antibodies has been identified. These antibodies can protect against lentiviral infection in …
Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B …
JM Binley, EA Lybarger, ET Crooks… - Journal of …, 2008 - Am Soc Microbiol
Identifying the viral epitopes targeted by broad neutralizing antibodies (NAbs) that
sometimes develop in human immunodeficiency virus type 1 (HIV-1)-infected subjects …
sometimes develop in human immunodeficiency virus type 1 (HIV-1)-infected subjects …
A humanized, nondepleting anti-CD4 antibody that blocks virus entry inhibits virus replication in rhesus monkeys chronically infected with simian immunodeficiency …
KA Reimann, R Khunkhun, W Lin… - AIDS research and …, 2002 - liebertpub.com
Therapeutic approaches that interfere with viral entry hold promise in preventing or treating
HIV infection. Hu5A8, a humanized monoclonal antibody against CD4, was previously …
HIV infection. Hu5A8, a humanized monoclonal antibody against CD4, was previously …
Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus
DN Sather, S Carbonetti, J Kehayia, Z Kraft… - Journal of …, 2012 - Am Soc Microbiol
Approximately 1% of those infected with HIV-1 develop broad and potent serum cross-
neutralizing antibody activities. It is unknown whether or not the development of such …
neutralizing antibody activities. It is unknown whether or not the development of such …
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
KO Saunders, RJ Edwards, K Tilahun… - Science translational …, 2022 - science.org
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb)
response, yet vaccine-mediated induction of such a response in primates remains a …
response, yet vaccine-mediated induction of such a response in primates remains a …