Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship
F Gao, G Huang, J Xiao - Medicinal research reviews, 2020 - Wiley Online Library
The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …
agents have been the major challenges in the control and treatment of cancer, making an …
Advances in chalcones with anticancer activities
C Karthikeyan, N SH Narayana Moorthy… - Recent patents on …, 2015 - ingentaconnect.com
Chalcones are naturally occurring compounds exhibiting broad spectrum biological
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
Chalcone scaffold in anticancer armamentarium: a molecular insight
Cancer is an inevitable matter of concern in the medicinal chemistry era. Chalcone is the
well exploited scaffold in the anticancer domain. The molecular mechanism of chalcone at …
well exploited scaffold in the anticancer domain. The molecular mechanism of chalcone at …
Chalcone derivatives: role in anticancer therapy
Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …
which are common simple chemical scaffolds found in many naturally occurring compounds …
Heterocyclic chalcone analogues as potential anticancer agents
Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as
Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two …
Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two …
Anticancer potential of natural chalcones: in vitro and in vivo evidence
R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …
decades. However, the discovery of new molecules with potential antitumor properties still …
Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Chalcones as promising lead compounds on cancer therapy
AJ Leon-Gonzalez, N Acero… - Current medicinal …, 2015 - ingentaconnect.com
Chalcones constitute a group of phenolic compounds that command an increasing interest
on cancer research. Natural chalcones are widespread through the plant kingdom. The most …
on cancer research. Natural chalcones are widespread through the plant kingdom. The most …
Molecular mechanisms of antiproliferative effects of natural chalcones
R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …
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