The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis

M Njoroge, NM Njuguna, P Mutai… - Chemical …, 2014 - ACS Publications
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

Natural products for neglected diseases: a review

JR Ioset - Current Organic Chemistry, 2008 - ingentaconnect.com
Leishmaniasis, sleeping sickness (Human African Trypanosomiasis), Chagas' disease
(American Trypanosomiasis) and malaria are tropical parasitic diseases responsible for high …

Natural products as a source for treating neglected parasitic diseases

D Ndjonka, LN Rapado, AM Silber, E Liebau… - International Journal of …, 2013 - mdpi.com
Infectious diseases caused by parasites are a major threat for the entire mankind, especially
in the tropics. More than 1 billion people world-wide are directly exposed to tropical …

Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease

CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

AG Tempone, P Pieper, SET Borborema… - Natural product …, 2021 - pubs.rsc.org
Covering: 2000 up to 2021 Natural products are an important resource in drug discovery,
directly or indirectly delivering numerous small molecules for potential development as …

Natural products as trypanocidal, antileishmanial and antimalarial drugs.

A Fournet, V Muñoz - Current Topics in medicinal chemistry, 2002 - europepmc.org
Parasitic diseases caused by protozoa as Leishmania, Trypanosome or Plasmodium are
responsible for more than three millions deaths annually throughout the developing …

Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis

MM Salem, KA Werbovetz - Current medicinal chemistry, 2006 - ingentaconnect.com
Millions of people in the developing world are affected by diseases caused by the
kinetoplastid parasites: the leishmaniases, African trypanosomiasis, and Chagas disease. In …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[PDF][PDF] Leishmaniasis and Chagas disease–neglected tropical diseases: treatment updates

LS Sangenito, V da Silva Santos… - Current Topics in …, 2019 - academia.edu
The World Health Organization (WHO)[1] has listed 20 neglected tropical diseases (NTDs),
including infections caused by viruses, bacteria, fungi and protozoa. Together, these …