Emerging evidence suggests that amino acids dictate the effector functions of immune cells;
however, whether and how phenylalanine (Phe) orchestrates the polarization of …

Methionine (Met) is an essential and multifunctional nutrient in vertebrate diets. It is a
precursor of S-adenosylmethionine (SAM), the methyl donor for DNA methylation, which has …

Macrophages, owning variable phenotypes and diverse functions, were becoming the target
cells in inflammatory, infectious and autoimmune diseases. In the present study, we …

Metabolites play critical roles in macrophage polarization and in their function in response to
infection and inflammation. α-aminobutyric acid (AABA), a non-proteinogenic amino acid …

Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following
shock and/or liver surgery. Gut microbiota and their metabolites are key upstream …

Increasing evidence support that cellular amino acid metabolism shapes the fate of immune
cells; however, whether aspartate metabolism dictates macrophage function is still …

Non-resolving inflammatory monocytes/macrophages are critically involved in the
pathogenesis of chronic inflammatory diseases. However, mechanisms of macrophage …

Pseudomonas quinolone signal (PQS) is a quorum-sensing molecule associated with
Pseudomonas aeruginosa that regulates quorum sensing, extracellular vesicle biogenesis …

Macrophage activation is an important process in controlling infection, but persistent
macrophage activation leads to chronic inflammation and diseases, such as tumor …

Intracellular metabolic programs tightly regulate the functions of macrophages, and previous
studies have shown that serine mainly shapes the macrophage function via one-carbon …