Angiogenesis in the pathophysiology of schizophrenia—a comprehensive review and a conceptual hypothesis

R Lopes, R Soares, R Coelho, M Figueiredo-Braga - Life sciences, 2015 - Elsevier
Schizophrenia (SZ) is a severe mental disorder poorly elucidated from the etiopathogenesis
prism. Recently, several micro-and macro-vascular abnormalities have been consistently …

Microvascular anomaly conditions in psychiatric disease. Schizophrenia–angiogenesis connection

P Katsel, P Roussos, M Pletnikov… - … & biobehavioral reviews, 2017 - Elsevier
Schizophrenia (SZ) is a severe mental disorder with unknown etiology and elusive
neuropathological and neurobiological features have been a focus of many theoretical …

Schizophrenia and cancer: is angiogenesis a missed link?

R Lopes, R Soares, M Figueiredo-Braga, R Coelho - Life sciences, 2014 - Elsevier
Cancer prevalence and risk in schizophrenia (SZ) patients, as well as their implicated
molecular pathways, is a debate that has become increasingly appreciated, despite lacking …

It takes two to tango: Widening our understanding of the onset of schizophrenia from a neuro-angiogenic perspective

BS Casas, D Arancibia-Altamirano… - Frontiers in Cell and …, 2022 - frontiersin.org
Schizophrenia is a chronic debilitating mental disorder characterized by perturbations in
thinking, perception, and behavior, along with brain connectivity deficiencies …

Brain vasculature disturbance in schizophrenia

S Puvogel, V Palma, IEC Sommer - Current opinion in psychiatry, 2022 - journals.lww.com
In some patients with SZ, a vulnerable brain endothelium may be interacting with
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …

Theories of schizophrenia: a genetic-inflammatory-vascular synthesis

DR Hanson, II Gottesman - BMC medical genetics, 2005 - Springer
Background Schizophrenia, a relatively common psychiatric syndrome, affects virtually all
brain functions yet has eluded explanation for more than 100 years. Whether by …

Functional genomics indicate that schizophrenia may be an adult vascular-ischemic disorder

HW Moises, D Wollschläger, H Binder - Translational psychiatry, 2015 - nature.com
In search for the elusive schizophrenia pathway, candidate genes for the disorder from a
discovery sample were localized within the energy-delivering and ischemia protection …

Structural and functional features of developing brain capillaries, and their alteration in schizophrenia

M Carrier, J Guilbert, JP Lévesque… - Frontiers in Cellular …, 2021 - frontiersin.org
Schizophrenia affects more than 1% of the world's population and shows very high
heterogeneity in the positive, negative, and cognitive symptoms experienced by patients …

Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function

BS Casas, G Vitória, CP Prieto, M Casas… - Molecular …, 2022 - nature.com
Schizophrenia (SZ) is a complex neuropsychiatric disorder, affecting 1% of the world
population. Long-standing clinical observations and molecular data have pointed to a …

RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation

HF North, C Weissleder, M Bitar, G Barry, JM Fullerton… - Schizophrenia, 2024 - nature.com
A subgroup of schizophrenia cases with elevated inflammation have reduced neurogenesis
markers and increased macrophage density in the human subependymal zone (SEZ; also …