Folate-based radiotracers for nuclear imaging and radionuclide therapy

L Wagner, B Kenzhebayeva, B Dhaini… - Coordination Chemistry …, 2022 - Elsevier
Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian
or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is …

[HTML][HTML] Folate-based radiotracers for PET imaging—update and perspectives

C Müller - Molecules, 2013 - mdpi.com
The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung
cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive …

[HTML][HTML] Development of folate receptor− targeted pet radiopharmaceuticals for tumor imaging—a bench-to-bedside journey

SD Boss, SM Ametamey - Cancers, 2020 - mdpi.com
The folate receptor-α (FR-α) is overexpressed in many epithelial cancers, including ovary,
uterus, kidneys, breast, lung, colon and prostate carcinomas, but shows limited expression …

Folic acid conjugates for nuclear imaging of folate receptor–positive cancer

C Müller, R Schibli - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its
distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR …

Fluorine-18 Click Radiosynthesis and Preclinical Evaluation of a New 18F-Labeled Folic Acid Derivative

TL Ross, M Honer, PYH Lam, TL Mindt… - Bioconjugate …, 2008 - ACS Publications
The folate receptor (FR) is highly expressed on most epithelial cancer cells, while normal
cells show only restricted expression of FR. As a result, the FR is an ideal target for receptor …

[HTML][HTML] New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging

LL Radford, S Fernandez, R Beacham, R El Sayed… - Pharmaceuticals, 2019 - mdpi.com
Overexpression of folate receptors (FRs) on different tumor types (eg, ovarian, lung) make
FRs attractive in vivo targets for directed diagnostic/therapeutic agents. Currently, no …

Folate based radiopharmaceuticals for imaging and therapy of cancer and inflammation

C Muller - Current pharmaceutical design, 2012 - ingentaconnect.com
Frequent overexpression of the folate receptor (FR) on a variety of tumor types and on
activated macrophages makes this re-ceptor an interesting target for both imaging and …

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

CR Fischer, C Müller, J Reber, A Müller… - Bioconjugate …, 2012 - ACS Publications
The folate receptor (FR) is upregulated in various cancer types (FR-α isoform) and in
activated macrophages (FR-β isoform) which are involved in inflammatory and autoimmune …

18F‐labeled folic acid derivatives for imaging of the folate receptor via positron emission tomography

H Schieferstein, TL Ross - Journal of Labelled Compounds and …, 2013 - Wiley Online Library
The folate receptor (FR) is already known as a proven target in diagnostics and therapy of
cancer. Furthermore, the FR is involved in inflammatory and autoimmune diseases. The …

Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting

C Müller, A Hohn, PA Schubiger, R Schibli - European journal of nuclear …, 2006 - Springer
Purpose The folate receptor (FR) is a valuable tumour marker, since it is frequently
overexpressed on various cancer types. The purpose of the present study was to pre …