Both experimental and epidemiological evidence support the concept that the in utero
environment can influence an individual's risk of breast cancer in adult life. Recently …

Perinatal events and conditions, notably birth weight, are associated with breast cancer risk
in offspring, and correlates of mammary gland mass are predictors of breast cancer risk …

The hypothesis that in utero exposure to pregnancy hormones, notably estrogens, is related
to the occurrence of breast cancer in the offspring has been examined in a number of …

The'cancer stem cell hypothesis' posits that cancers, including breast cancer, arise in tissue
stem or progenitor cells. If this is the case, then it follows that the risk for developing breast …

Introduction In humans, an early full-term pregnancy reduces lifetime breast cancer risk by
up to 50% whereas a later pregnancy (> 35 years old) can increase lifetime risk. Several …

Epidemiological, clinical, and experimental data indicate that the risk of developing breast
cancer is strongly dependent on the ovary and on endocrine conditions modulated by …

Like other organs, the breast contains rare somatic stem cells (SCs) that are long-lived and
slowly dividing. In the adult breast, they are closely regulated in areas located along the …

Risk factors for breast cancer—documented by intensive epidemiological investigations and
viewed in the context of general principles of carcinogenesis—can be integrated to an …

A completed pregnancy at a young age reduces a woman's lifetime risk of breast cancer by
up to 50%. A similar protective effect of an early pregnancy has been observed in rodent …

The primitive breast develops in utero and during infancy breast growth largely parallels the
growth of the child. At puberty, the GnRH pulse generator starts up, initially with just 1–2 …