Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

Despite advances in our understanding of the mechanisms underlying the progression of
chronic kidney disease and the development of fibrosis, only limited efficacious therapies …

Renal fibrosis arises by the generation of matrix-producing fibroblasts and myofibroblasts
through the epithelial–mesenchymal transition (EMT), a process in which epithelial cells …

The TGF-β/Smad3 signaling pathway is an important process in the pathogenesis of kidney
fibrosis. However, the molecular mechanisms are not completely elucidated. The current …

Diabetic nephropathy (DN) commonly causes end-stage renal disease (ESRD). Increasing
evidence indicates that abnormal miRNA expression is tightly associated with chronic …

Renal interstitial fibrosis (RIF) is the common irreversible pathway by which chronic kidney
disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal …

Tubulointerstitial fibrosis impacts renal prognosis of focal segmental glomerulosclerosis
(FSGS). Based on transcriptomic analysis, we found that the level of LOC105375913 was …

Background Tubulointerstitial fibrosis (TIF) is one of the main pathological features of
various progressive renal damages and chronic kidney diseases. Mesenchymal stromal …

Introduction Aldosterone is a mediator of progressive renal disease, but the mechanisms for
aldosterone-mediated renal impairment in mice with diabetes are not fully defined. Methods …

Recent studies have indicated that the development of acute and chronic kidney disease
including renal fibrosis is associated with endoplasmic reticulum (ER) stress. S100 calcium …