Syringic acid (SA), a natural polyphenol found in fruits and vegetables, is claimed to show
notable hepatoprotection. Nevertheless, low solubility and bioavailability hamper the …

In this study, syringic acid–loaded TPGS liposome (SA-TPGS-Ls) was successfully prepared
to improve oral bioavailability of syringic acid (SA). SA is a natural and notable antioxidant …

Silybin, a natural compound for treating liver disease, has been shown to provide diverse
biological activities such as anticancer, antioxidant and hepatoprotective. However, it is still …

Silymarin has been widely used as a hepatoprotective drug in the treatment of various liver
diseases, yet its effectiveness is affected by its poor water solubility and low bioavailability …

In order to enhance oral bioavailability and liver targeting delivery of silybin, two amphiphilic
hyaluronic acid derivatives, hyaluronic acid-deoxycholic acid (HA-adh-DOCA) and …

Introduction Silybin (SLB) as an effective hepatoprotective phytomedicine has been limited
by its hydrophobicity, poor bioavailability and accumulation at lesion sites. Additionally …

In this study, galactosamine-modified poly (ethylene glycol)-poly (lactide)(Gal-PEG-PLA)
polymers were synthesized and Gal-PEG-PLA/D-α-tocopherol polyethylene glycol 1000 …

Solid lipid nanoparticles (SLN) are the most promising delivery system that improves the
stability, bioavailability and controlled release of food bioactive compounds. The delivery of …

Background The purpose of this study was to develop a novel silymarin-loaded solid
nanoparticle system with enhanced oral bioavailability and an ability to provide excellent …

Silibinin (SB) and pomegranate oil (PO) present therapeutic potential due to antioxidant
activity, but the biological performance of both bioactives is limited by their low aqueous …