Variation in DNA methylation between individuals has been shown to be influenced by both
genetic and environmental factors. However, the relative impact of genetic and non-genetic …

DNA methylation is an essential epigenetic process in mammals, intimately involved in gene
regulation. Here we address the extent to which genetics, sex, and pregnancy influence …

The view of maternal effects (nongenetic maternal environmental influence on offspring
phenotype) has changed from one of distracting complications in evolutionary genetics to an …

Background DNA methylation is a contributing factor to both rare and common human
diseases, and plays a major role in development and gene silencing. While the variation of …

The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and
the progression of many cancers, and it plays an important role in gametic imprinting. To …

Genetic polymorphisms can shape the global landscape of DNA methylation, by either
changing substrates for DNA methyltransferases or altering the DNA binding affinity of cis …

Background Despite the important role DNA methylation plays in transcriptional regulation,
the transgenerational inheritance of DNA methylation is not well understood. The genetic …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

Despite the increasing knowledge about DNA methylation, the understanding of human
epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we …

Traditionally, DNA methylation has been thought of as being involved in gene silencing, but
work in recent years has shown a more complex picture, and the relationship between DNA …