Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Arachidonic acid metabolism in health and disease

Y Zhang, Y Liu, J Sun, W Zhang, Z Guo, Q Ma - MedComm, 2023 - Wiley Online Library
Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Effects of arachidonic acid metabolites on cardiovascular health and disease

Y Zhou, H Khan, J Xiao, WS Cheang - International journal of molecular …, 2021 - mdpi.com
Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis

L Badimon, G Vilahur, B Rocca… - Cardiovascular …, 2021 - academic.oup.com
Arachidonic acid is one of the most abundant and ubiquitous ω-6 polyunsaturated fatty acid,
present in esterified form in the membrane phospholipids of all mammalian cells and …

Arachidonic acid cascade in endothelial pathobiology

NV Bogatcheva, MG Sergeeva, SM Dudek… - Microvascular …, 2005 - Elsevier
Arachidonic acid (AA) and its metabolites (eicosanoids) represent powerful mediators, used
by organisms to induce and suppress inflammation as a part of the innate response to …

Arachidonic acid metabolites in cardiovascular and metabolic diseases

T Sonnweber, A Pizzini, M Nairz, G Weiss… - International journal of …, 2018 - mdpi.com
Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis

CAC Hyde, S Missailidis - International immunopharmacology, 2009 - Elsevier
Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due
to growing evidence of their significant role in cancer biology. Thus, inhibitors of the AA …

The eicosanoids: cyclooxygenase, lipoxygenase and epoxygenase pathways

WL Smith, RC Murphy - Biochemistry of lipids, lipoproteins and membranes, 2016 - Elsevier
Eicosanoids are bioactive, oxygenated polyunsaturated fatty acids (FAs) derived from the
nutritionally essential 20 carbon fatty acid, arachidonic acid (AA). Oxidation of other …

Control of arachidonate levels within inflammatory cells

FH Chilton, AN Fonteh, ME Surette, M Triggiani… - … et Biophysica Acta (BBA …, 1996 - Elsevier
Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been …

[HTML][HTML] Synopsis of arachidonic acid metabolism: A review

VS Hanna, EAA Hafez - Journal of advanced research, 2018 - Elsevier
Abstract Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double
bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and …