The detection of nucleic acids by the innate immune system is an essential host response
during viral infection. In recent years, a number of immune sensors capable of recognizing …

The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …

PYHIN proteins: center stage in DNA sensing | Nature Immunology Skip to main content
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A defining feature of viral central nervous system (CNS) infection is the rapid onset of severe
neuroinflammation. However, the mechanisms underlying glial responses to replicative …

The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic
double-stranded DNA (dsDNA). On sensing dsDNA, the IFI16 protein induces the …

The innate immune response depends on the ability of immune cells to detect pathogens
through germline-encoded pattern recognition receptors (PRRs). Recently discovered PRRs …

Cumulative evidence indicates that activation of innate immune responses in the central
nervous system (CNS) induces the expression of type 1 interferons (T1 IFNs), a family of …

Astrocytes, together with microglia and macrophages, participate in innate inflammatory
responses in the CNS. Although inflammatory mediators such as interferons generated by …

Deregulated innate immune responses that result in increased levels of type I interferons
(IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic …

The innate immune response is the first line of defense against infection and relies on the
ability of immune cells to detect the presence of infection through germline‐encoded pattern …