Autonomic imbalance between the sympathetic and parasympathetic nervous systems
contributes to the progression of chronic heart failure (HF). Preclinical studies have …

Heart failure (HF) is one of the most prevalent cardiovascular diseases and is associated
with high morbidity and mortality. Mechanistically, HF is characterized by an overactive …

Heart failure with reduced left ventricular ejection fraction is a progressive disease that
claims> 352,000 lives annually in the United States alone. Despite the development of an …

Heart Failure (HF) is associated with sustained acti-vation of the sympathetic nervous
system and withdrawal of parasympathetic tone. Autonomic nervous system modulation has …

Autonomic dysregulation is a feature of chronic heart failure (HF) and is characterized by a
sustained increase of sympathetic drive and by withdrawal of parasympathetic activity. Both …

Chronic heart failure (HF) is associated with autonomic dysregulation characterized by a
sustained increase in sympathetic drive and by withdrawal of parasympathetic activity …

Advances in heart failure (HF) therapeutics over the last 20 years have led to widespread
acceptance and use of oral antagonists of the renin–angiotensin–aldosterone (RAAS) and …

Sympathovagal imbalance contributes to progressive worsening of heart failure (HF) and is
associated with untoward clinical outcomes. Based on compelling pre-clinical studies that …

Autonomic imbalance with increased adrenergic and reduced parasympathetic activity is
involved in the development and progress of heart failure (HF). Experimental data have …

Objectives: The aim of this study was to evaluate the effects of invasive vagal nerve
stimulation (VNS) in patients with chronic heart failure (HF) and reduced ejection fraction …