Early interventions after acute traumatic brain injury (TBI) provide clinicians an opportunity to
prevent secondary injury and improve neurologic outcomes. One avenue is to optimize brain …

Injury Phase-II (BOOST-II),” a phase II randomized trial. David et al (1) are to be
congratulated for completing this well-designed and executed study. BOOST-II was planned …

In a recent article in Critical Care Medicine, Okonkwo et al (1) reported the results on their
ambitious and insightful Brain Oxygenation Optimization in Severe Traumatic Brain Injury …

Over the past 4 decades, the neurosciences critical care community witnessed many
changes to guidelines and management protocols for brain-injured patients. Despite all …

Cerebral autoregulation (CA) is a physiologic process whereby adequate cerebral blood
flow is maintained according to cerebral metabolic needs. It is a very important mechanism …

Trauma is the leading cause of death and disability in the first 5 decades of life (1), and brain
injury is the principal cause of death in the trauma population (2). According to the Centers …

Optimization of cerebral perfusion pressure (CPP) is a cornerstone of the management of
head-injured patients in intensive care. Unfortunately, there is still no consensus on the best …

Traumatic brain injury (TBI) covers a range of morphologic and functional lesions, grouping
different entities (such as an expanding mass above the dura or a diffuse axonal injury) …

Data presented in the guidelines suggest that a CPP of 70 mm Hg or greater is sufficient for
adequate perfusion of neuronal cells in the absence of other brain pathology. 2 The …

OBJECTIVES: To examine if increasing blood pressure improves brain tissue oxygenation
(PbtO 2) in adults with severe traumatic brain injury (TBI). DESIGN: Retrospective review of …