Glucocorticoids

IM Adcock, S Mumby - Pharmacology and Therapeutics of Asthma and …, 2017 - Springer
The most effective anti-inflammatory drugs used to treat patients with airways disease are
topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to …

Glucocorticoids: mechanisms of action and anti‐inflammatory potential in asthma

VHJ Van Der Velden - Mediators of inflammation, 1998 - Wiley Online Library
Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the
treatment of asthma. The anti‐inflammatory effects are mediated either by direct binding of …

Efficacy and safety of inhaled corticosteroids in asthma

PJ Barnes, S Pedersen - American Review of Respiratory Disease, 1993 - atsjournals.org
Inhaled glucocorticosteroids have now become first-line therapy for the treatment of chronic
asthma in many countries. They are the most effective asthma therapy currently available …

Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network.

AK Kamada, SJ Szefler, RJ Martin… - American journal of …, 1996 - atsjournals.org
Asthma is now regarded as an inflammatory disease, and inhaled glucocorticoids (iGCs) are
recommended earlier in the course of treatment of patients with this disorder. Although iGCs …

Mechanisms of glucocorticoid action and insensitivity in airways disease

C Boardman, L Chachi, A Gavrila, CR Keenan… - Pulmonary …, 2014 - Elsevier
Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …

Glucocorticoid therapy for asthma: clinical pharmacology

SJ Szefler - Journal of allergy and clinical immunology, 1991 - Elsevier
We are now well aware that inflammation plays an important role in the pathogenesis of
asthma. This awareness comes at a time when we question the etiology of increased …

Clinical pharmacology of corticosteroids

DM Williams - Respiratory care, 2018 - rc.rcjournal.com
Corticosteroids have numerous applications in treating inflammation and diseases of
immune function based on their significant anti-inflammatory and immunosuppressive …

Update on glucocorticoid action and resistance

K Ito, KF Chung, IM Adcock - Journal of Allergy and Clinical Immunology, 2006 - Elsevier
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Inhaled glucocorticoids for asthma

PJ Barnes - New England Journal of Medicine, 1995 - Mass Medical Soc
Glucocorticoids are the most effective therapy available for patients with asthma. They may
be administered either orally or, much more safely, by inhalation. With the recognition that …

[引用][C] Pharmacodynamics and pharmacokinetics of inhaled glucocorticoids

M Johnson - Journal of Allergy and Clinical Immunology, 1996 - Elsevier
Research during the past two decades has shown that the inflammatory component of
bronchial asthma has a highly complex and multifactorial pathophysiology. Inhaled …