The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are
essential for germinal center formation, affinity maturation, and the development of most high …

Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-
wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh …

The generation of high-affinity antibodies (Abs) plays a critical role in the neutralization and
clearance of pathogens and subsequent host survival after natural infection with a variety of …

CD4+ T helper (Th) cells play an instrumental role in orchestrating adaptive immune
responses to invading pathogens through their ability to differentiate into specialized effector …

The success of most vaccines relies on the generation of antibodies to provide protection
against subsequent infection; this in turn depends on a robust germinal centre (GC) …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Effective humoral immunity depends on the support of B cell responses by T follicular helper
(Tfh) cells. Although it has been proposed that Tfh cell differentiation requires TB …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …