PRRX1 loss‐of‐function mutations underlying familial atrial fibrillation
XJ Guo, XB Qiu, J Wang, YH Guo… - Journal of the …, 2021 - Am Heart Assoc
Background Atrial fibrillation (AF) is the most common form of clinical cardiac dysrhythmia
responsible for thromboembolic cerebral stroke, congestive heart failure, and death …
responsible for thromboembolic cerebral stroke, congestive heart failure, and death …
A Variant Noncoding Region Regulates Prrx1 and Predisposes to Atrial Arrhythmias
FM Bosada, MR Rivaud, JS Uhm, S Verheule… - Circulation …, 2021 - Am Heart Assoc
Rationale: Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed in clinical
practice. Genome-wide association studies have identified AF-associated common variants …
practice. Genome-wide association studies have identified AF-associated common variants …
Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential
Background—Atrial fibrillation (AF) affects over 33 million individuals worldwide. Genome-
wide association studies have identified at least 30 AF loci, but the mechanisms through …
wide association studies have identified at least 30 AF loci, but the mechanisms through …
[HTML][HTML] A novel PRRX1 loss-of-function variation contributing to familial atrial fibrillation and congenital patent ductus arteriosus
ZP Ke, GF Zhang, YH Guo, YM Sun, J Wang… - … and molecular biology, 2022 - SciELO Brasil
Atrial fibrillation (AF) represents the most common type of sustained cardiac arrhythmia in
humans and confers a significantly increased risk for thromboembolic stroke, congestive …
humans and confers a significantly increased risk for thromboembolic stroke, congestive …
Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing …
Background Genome-wide association studies (GWAS) have identified common genetic
variants that predispose to atrial fibrillation (AF). It is unclear whether rare and low-frequency …
variants that predispose to atrial fibrillation (AF). It is unclear whether rare and low-frequency …
[HTML][HTML] A SHOX2 loss-of-function mutation underlying familial atrial fibrillation
N Li, ZS Wang, XH Wang, YJ Xu, Q Qiao… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
Atrial fibrillation (AF), as the most common sustained cardiac arrhythmia, is associated with
substantially increased morbidity and mortality. Aggregating evidence demonstrates that …
substantially increased morbidity and mortality. Aggregating evidence demonstrates that …
Genome-wide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable …
Background—Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and
patients with AF have a significantly increased risk for ischemic stroke. Approximately 15 …
patients with AF have a significantly increased risk for ischemic stroke. Approximately 15 …
Association between ZFHX3 and PRRX1 Polymorphisms and Atrial Fibrillation Susceptibility from Meta‐Analysis
L Wu, M Chu, W Zhuang - International Journal of …, 2021 - Wiley Online Library
Background. Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent
studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In …
studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In …
Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation
RB Thorolfsdottir, G Sveinbjornsson, P Sulem… - Communications …, 2018 - nature.com
Most sequence variants identified hitherto in genome-wide association studies (GWAS) of
atrial fibrillation are common, non-coding variants associated with risk through unknown …
atrial fibrillation are common, non-coding variants associated with risk through unknown …
The genetic puzzle of familial atrial fibrillation
AAY Ragab, GDS Sitorus, BB Brundel… - Frontiers in …, 2020 - frontiersin.org
Atrial fibrillation (AF) is the most common clinical tachyarrhythmia. In Europe, AF is expected
to reach a prevalence of 18 million by 2060. This estimate will increase hospitalization for AF …
to reach a prevalence of 18 million by 2060. This estimate will increase hospitalization for AF …