[HTML][HTML] Human organoids for predictive toxicology research and drug development
T Matsui, T Shinozawa - Frontiers in Genetics, 2021 - frontiersin.org
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …
adult tissue stem cells via a process of self-organization that results in the formation of organ …
Organoid technology: Current standing and future perspectives
L Shariati, Y Esmaeili, S Haghjooy Javanmard… - Stem Cells, 2021 - academic.oup.com
Organoids are powerful systems to facilitate the study of individuals' disorders and
personalized treatments. This emerging technology has improved the chance of …
personalized treatments. This emerging technology has improved the chance of …
[HTML][HTML] Revolutionizing disease modeling: the emergence of organoids in cellular systems
R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …
through well-established protocols, while avoiding the ethical restrictions associated with …
Progress and potential in organoid research
G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
Biologically inspired approaches to enhance human organoid complexity
EM Holloway, MM Capeling, JR Spence - Development, 2019 - journals.biologists.com
Organoids are complex three-dimensional in vitro organ-like model systems. Human
organoids, which are derived from human pluripotent stem cells or primary human donor …
organoids, which are derived from human pluripotent stem cells or primary human donor …
Engineered organoids for biomedical applications
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …
rapidly emerging as powerful tools for biomedical applications. With their potential for …
[HTML][HTML] Next-generation liver medicine using organoid models
“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …
Concise review: organoids are a powerful tool for the study of liver disease and personalized treatment design in humans and animals
S Nantasanti, A de Bruin, J Rothuizen… - Stem cells …, 2016 - academic.oup.com
Organoids are three-dimensional culture systems in which adult stem cells and their
progeny grow and represent the native physiology of the cells in vivo. Organoids have been …
progeny grow and represent the native physiology of the cells in vivo. Organoids have been …
[HTML][HTML] Human organoids: New strategies and methods for analyzing human development and disease
NS Corsini, JA Knoblich - Cell, 2022 - cell.com
For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …
obtained primarily by experiments in animal models. While this has allowed researchers to …
[HTML][HTML] Organoids: a novel modality in disease modeling
Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …
that can recapitulate the architecture and function of human organs more accurately. Recent …