[HTML][HTML] Human organoids for predictive toxicology research and drug development

T Matsui, T Shinozawa - Frontiers in Genetics, 2021 - frontiersin.org
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

Organoid technology: Current standing and future perspectives

L Shariati, Y Esmaeili, S Haghjooy Javanmard… - Stem Cells, 2021 - academic.oup.com
Organoids are powerful systems to facilitate the study of individuals' disorders and
personalized treatments. This emerging technology has improved the chance of …

[HTML][HTML] Revolutionizing disease modeling: the emergence of organoids in cellular systems

R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Progress and potential in organoid research

G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Biologically inspired approaches to enhance human organoid complexity

EM Holloway, MM Capeling, JR Spence - Development, 2019 - journals.biologists.com
Organoids are complex three-dimensional in vitro organ-like model systems. Human
organoids, which are derived from human pluripotent stem cells or primary human donor …

Engineered organoids for biomedical applications

NR de Barros, C Wang, S Maity, A Peirsman… - Advanced Drug Delivery …, 2023 - Elsevier
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

[HTML][HTML] Next-generation liver medicine using organoid models

S Akbari, N Arslan, S Senturk, E Erdal - Frontiers in Cell and …, 2019 - frontiersin.org
“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …

Concise review: organoids are a powerful tool for the study of liver disease and personalized treatment design in humans and animals

S Nantasanti, A de Bruin, J Rothuizen… - Stem cells …, 2016 - academic.oup.com
Organoids are three-dimensional culture systems in which adult stem cells and their
progeny grow and represent the native physiology of the cells in vivo. Organoids have been …

[HTML][HTML] Human organoids: New strategies and methods for analyzing human development and disease

NS Corsini, JA Knoblich - Cell, 2022 - cell.com
For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

[HTML][HTML] Organoids: a novel modality in disease modeling

Z Heydari, F Moeinvaziri, T Agarwal, P Pooyan… - Bio-design and …, 2021 - Springer
Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …