The chromatin of the human genome was analyzed at three DNA size levels. At the first,
compartment level, two “gene spaces” were found many years ago: A GC-rich, gene-rich …

Recent investigations have revealed 1) that the isochores of the human genome group into
two super‐families characterized by two different long‐range 3D structures, and 2) that these …

Recent investigations have shown that isochores are characterized by a 3-D structure which
is primarily responsible for the topology of chromatin domains. More precisely, an analysis of …

Several hierarchical levels of DNA packaging are believed to exist in chromatin, starting
from a 10-nm chromatin fiber that is further packed into a 30-nm fiber. Transitions between …

In eukaryotic nucleosomes, DNA makes~ 1.7 superhelical turns around histone octamer.
However, there is a long-standing discrepancy between the nucleosome core structure …

The general model presented here for the formation of chromatin domains, LADs and TADs,
is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor …

Eukaryotic genomes store information on many levels, including their linear DNA sequence,
the posttranslational modifications of its constituents (epigenetic modifications), and its three …

Packaging of DNA into chromatin regulates DNA accessibility and consequently all DNA-
dependent processes. The nucleosome is the basic packaging unit of DNA forming arrays …

Chromatin rules | Nature Structural & Molecular Biology Skip to main content Thank you for
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Here we propose a new determinant for localization of nucleosomes along genomic DNA, in
addition to sequence-dependent features. The new specific class of chromatin scaling …